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 External Resources

 nature.c...-6.pdfhttps://www.nature.com/articles/s41593-022-01183-6.pdf  Article fulltext

 GSE202579https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE202579  NCBI GEO Dataset (GSE202579)

 GSE166548https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE166548  NCBI GEO Dataset (GSE166548, reused)

 GSE138891https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138891  NCBI GEO Dataset (GSE138891, reused)

 GSE132042https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE132042  NCBI GEO Dataset (GSE132042, reused)

 0000-0002-0642-1610https://orcid.org/0000-0002-0642-1610  ORCID identifier (Ludovico Cantuti-Castelvetri)

 0000-0002-0500-8218https://orcid.org/0000-0002-0500-8218  ORCID identifier (Martina Schifferer)

 0000-0002-9069-2594https://orcid.org/0000-0002-9069-2594  ORCID identifier (Arthur Liesz)

 0000-0001-6319-404Xhttps://orcid.org/0000-0001-6319-404X  ORCID identifier (Özgün Gökçe)

 0000-0001-5329-192Xhttps://orcid.org/0000-0001-5329-192X  ORCID identifier (Mikael Jakob Simons)

 043j0f473https://ror.org/043j0f473  ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)

 05591te55https://ror.org/05591te55  ROR identifier (05591te55, Ludwig-Maximilians-Universität München)

 025z3z560https://ror.org/025z3z560  ROR identifier (025z3z560, Munich Cluster for Systems Neurology)

 02kkvpp62https://ror.org/02kkvpp62  ROR identifier (02kkvpp62, Technical University of Munich)

 SCR_015058https://scicrunch.org/resolver/SCR_015058  SciCrunch identifier (RRID:SCR_015058, bcl2fastq)

 SCR_017344https://scicrunch.org/resolver/SCR_017344  SciCrunch identifier (RRID:SCR_017344, Cell Ranger)

 SCR_001881https://scicrunch.org/resolver/SCR_001881  SciCrunch identifier (RRID:SCR_001881, DAVID)

 SCR_014583https://scicrunch.org/resolver/SCR_014583  SciCrunch identifier (RRID:SCR_014583, FastQC)

 SCR_002285https://scicrunch.org/resolver/SCR_002285  SciCrunch identifier (RRID:SCR_002285, Fiji)

 SCR_008520https://scicrunch.org/resolver/SCR_008520  SciCrunch identifier (RRID:SCR_008520, FlowJo)

 SCR_014601https://scicrunch.org/resolver/SCR_014601  SciCrunch identifier (RRID:SCR_014601, ggplot2)

 SCR_002630https://scicrunch.org/resolver/SCR_002630  SciCrunch identifier (RRID:SCR_002630, GitHub)

 SCR_002798https://scicrunch.org/resolver/SCR_002798  SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_006553https://scicrunch.org/resolver/SCR_006553  SciCrunch identifier (RRID:SCR_006553, GRC)

 SCR_010233https://scicrunch.org/resolver/SCR_010233  SciCrunch identifier (RRID:SCR_010233, Illumina)

 SCR_003070https://scicrunch.org/resolver/SCR_003070  SciCrunch identifier (RRID:SCR_003070, ImageJ)

 SCR_007370https://scicrunch.org/resolver/SCR_007370  SciCrunch identifier (RRID:SCR_007370, Imaris)

 SCR_012155https://scicrunch.org/resolver/SCR_012155  SciCrunch identifier (RRID:SCR_012155, LightCycler)

 SCR_008624https://scicrunch.org/resolver/SCR_008624  SciCrunch identifier (RRID:SCR_008624, MatPlotLib)

 SCR_016620https://scicrunch.org/resolver/SCR_016620  SciCrunch identifier (RRID:SCR_016620, Metascape)

 SCR_001905https://scicrunch.org/resolver/SCR_001905  SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)

 SCR_018132https://scicrunch.org/resolver/SCR_018132  SciCrunch identifier (RRID:SCR_018132, seaborn)

 SCR_007322https://scicrunch.org/resolver/SCR_007322  SciCrunch identifier (RRID:SCR_007322, Seurat)

 SCR_005223https://scicrunch.org/resolver/SCR_005223  SciCrunch identifier (RRID:SCR_005223, STRING)

 SCR_016345https://scicrunch.org/resolver/SCR_016345  SciCrunch identifier (RRID:SCR_016345, TensorFlow)

 SCR_019186https://scicrunch.org/resolver/SCR_019186  SciCrunch identifier (RRID:SCR_019186, tidyverse)

 SCR_008954https://scicrunch.org/resolver/SCR_008954  SciCrunch identifier (RRID:SCR_008954, TrakEM2)

 github.c...rogliahttps://github.com/ISD-SystemsNeuroscience/Aging_Oligos_Microglia  Supplemental material (code)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM1_ESM.pdf  Supplemental material (reporting summary)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM2_ESM.xlsx  Supplemental material (table)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM3_ESM.xlsx  Supplemental material (table)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM4_ESM.xlsx  Supplemental material (table)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM5_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM6_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM7_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM8_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM9_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM10_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM11_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM12_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM13_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM14_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41593-022-01183-6/MediaObjects/41593_2022_1183_MOESM15_ESM.xlsx  Supplemental material (source data)