Adinda Wens
Universitätsmedizin Göttingen
Institut für Neuroimmunologie und Multiple
Sklerose Forschung
Von-Siebold-Str. 3 a, 37075 Göttingen
Tel: +49-(0)-551-39-61160
E-mail: adinda.wens@med.uni-goettingen.de
View primary antibody
Basic data
| PID | primary-0039 |
| EPIC PID | primary-0039 |
| Research group | RG Stadelmann-Nessler |
| Quality (mean) | no score (0.00) |
| Sharing level | Public |
Antibody data
| Antigen symbol | APP |
| Antibody Registry ID(s) | AB_94882 |
| Name | Anti-APP A4 Antibody |
| Alternative name | peptidase nexin-II |
| Lab ID | |
| Tag / Fluorophore | |
| Raised in | mouse |
| Reacts with | canine, Human, Mouse, monkey, pig, Rat, fish |
| Clone | 22C11 |
| Isotype | IgG1 |
| Clonality | monoclonal |
| Demasking | unknown |
| Antigen | Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein. |
| Crafted By | company |
| Company / Manufacturer | Merck Millipore |
| Catalog no. | MAB348 |
| Lot no. | |
| Description | MBExC: primary-0592 Immunofluorescence Immunohistochemistry: 5-10 μg/mL on 4% paraformaldehyde/15% picric acid perfused and fixed rat spinal cord. 22C11 also works in paraffin embedded tissues but at lower dilutions (1:10-1:20). Western blot: reducing conditions, 10μg/ml. Optimal working dilutions and protocols must be determined by the end user. |
| Localization | |
| Storage instruction | Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| Receipt date | 2021-11-01 00:00:00 |
| Preparation date | 2021-11-11 00:00:00 |
| Created by | , |
| Last modified | , |
External links
Applications
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Linked publications
Concurrent axon and myelin destruction differentiates X‐linked adrenoleukodystrophy from multiple sclerosis
Bergner CG, Genc N, Hametner S, Franz J, Meer F, Mitkovski M, Weber MS, Stoltenburg‐Didinger G, Kühl J, Köhler W, Brück W, Gärtner J, Stadelmann C
Glia 2021 : 10.1002/glia.24042
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, Damkou A, Zampar S, Wirths O, Thalmann M, Simons M, Saito T, Saido T, Krueger-Burg D, Kawaguchi R, Willem M, Haass C, Geschwind D, Ehrenreich H, Stassart R, Nave K
Nature 2023 : 10.1038/s41586-023-06120-6
