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 External Resources

 nature.c...stickyhttps://www.nature.com/articles/s41586-023-06120-6.pdf?pdf=button%20sticky  Article fulltext

 GSE178304https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178304  NCBI GEO Dataset (GSE178304)

 GSE178296https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178296  NCBI GEO Dataset (GSE178296)

 GSE208683https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE208683  NCBI GEO Dataset (GSE208683)

 GSE178295https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178295  NCBI GEO Dataset (GSE178295)

 0000-0003-2868-6932https://orcid.org/0000-0003-2868-6932  ORCID identifier (Constanze Depp)

 0000-0002-7104-7215https://orcid.org/0000-0002-7104-7215  ORCID identifier (Ting Sun)

 0000-0002-0308-0144https://orcid.org/0000-0002-0308-0144  ORCID identifier (Lena Spieth)

 0000-0001-7913-2716https://orcid.org/0000-0001-7913-2716  ORCID identifier (Agnes A. Steixner-Kumar)

 0000-0002-9535-9395https://orcid.org/0000-0002-9535-9395  ORCID identifier (Torben Ruhwedel)

 0000-0002-2902-7165https://orcid.org/0000-0002-2902-7165  ORCID identifier (Wiebke Möbius)

 0000-0003-3507-9604https://orcid.org/0000-0003-3507-9604  ORCID identifier (Gesine Saher)

 0000-0002-7710-5738https://orcid.org/0000-0002-7710-5738  ORCID identifier (Hauke B. Werner)

 0000-0002-5082-0790https://orcid.org/0000-0002-5082-0790  ORCID identifier (Alkmini Damkou)

 0000-0003-0134-0974https://orcid.org/0000-0003-0134-0974  ORCID identifier (Silvia Zampar)

 0000-0002-4115-0334https://orcid.org/0000-0002-4115-0334  ORCID identifier (Oliver Wirths)

 0000-0002-0610-210Xhttps://orcid.org/0000-0002-0610-210X  ORCID identifier (Maik Thalmann)

 0000-0001-5329-192Xhttps://orcid.org/0000-0001-5329-192X  ORCID identifier (Mikael Jakob Simons)

 0000-0003-1970-6903https://orcid.org/0000-0003-1970-6903  ORCID identifier (Takaomi Saido)

 0000-0001-5597-6287https://orcid.org/0000-0001-5597-6287  ORCID identifier (Dilja Krueger-Burg)

 0000-0002-4869-1627https://orcid.org/0000-0002-4869-1627  ORCID identifier (Christian Haass)

 0000-0003-2896-3450https://orcid.org/0000-0003-2896-3450  ORCID identifier (Daniel Geschwind)

 0000-0001-8371-5711https://orcid.org/0000-0001-8371-5711  ORCID identifier (Hannelore Maria Ehrenreich)

 0000-0001-8724-9666https://orcid.org/0000-0001-8724-9666  ORCID identifier (Klaus-Armin Nave)

 2/61https://rdp.sfb274.de/archive/2/61  Research Data Archive (supplemental material)

 043j0f473https://ror.org/043j0f473  ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)

 03av75f26https://ror.org/03av75f26  ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

 025z3z560https://ror.org/025z3z560  ROR identifier (025z3z560, Munich Cluster for Systems Neurology)

 02kkvpp62https://ror.org/02kkvpp62  ROR identifier (02kkvpp62, Technical University of Munich)

 SCR_018000https://scicrunch.org/resolver/SCR_018000  SciCrunch identifier (RRID:SCR_018000, arivis Vision4D)

 SCR_017344https://scicrunch.org/resolver/SCR_017344  SciCrunch identifier (RRID:SCR_017344, Cell Ranger)

 SCR_015687https://scicrunch.org/resolver/SCR_015687  SciCrunch identifier (RRID:SCR_015687, DESeq2)

 SCR_014583https://scicrunch.org/resolver/SCR_014583  SciCrunch identifier (RRID:SCR_014583, FastQC)

 SCR_012919https://scicrunch.org/resolver/SCR_012919  SciCrunch identifier (RRID:SCR_012919, featureCounts)

 SCR_002285https://scicrunch.org/resolver/SCR_002285  SciCrunch identifier (RRID:SCR_002285, Fiji)

 SCR_002798https://scicrunch.org/resolver/SCR_002798  SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_018863https://scicrunch.org/resolver/SCR_018863  SciCrunch identifier (RRID:SCR_018863, Imspector)

 SCR_016340https://scicrunch.org/resolver/SCR_016340  SciCrunch identifier (RRID:SCR_016340, MAST)

 SCR_007322https://scicrunch.org/resolver/SCR_007322  SciCrunch identifier (RRID:SCR_007322, Seurat)

 SCR_015899https://scicrunch.org/resolver/SCR_015899  SciCrunch identifier (RRID:SCR_015899, STAR)

 SCR_005223https://scicrunch.org/resolver/SCR_005223  SciCrunch identifier (RRID:SCR_005223, STRING)

 SCR_018217https://scicrunch.org/resolver/SCR_018217  SciCrunch identifier (RRID:SCR_018217, UMAP)

 SCR_013672https://scicrunch.org/resolver/SCR_013672  SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM1_ESM.pdf  Supplemental material

 github.c...nt.githttps://github.com/TSun-tech/AD_MyelinMutant.git  Supplemental material (code)

 goeseek.gwdguser.de/studies/31https://goeseek.gwdguser.de/studies/31  Supplemental material (goeseek study)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM2_ESM.pdf  Supplemental material (reporting summary)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM3_ESM.xlsx  Supplemental material (table)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM4_ESM.xlsx  Supplemental material (table)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM5_ESM.xlsx  Supplemental material (source data)