View publication

↩ Back to all publications
Working Groups RG Ehrenreich, RG Nave, RG Simons
Open AccessOpen Access Yes
Publication TypeJournal Article
Peer ReviewedYes
PMIDPubMed ID 37258678
DOIDOI 10.1038/s41586-023-06120-6
Publication Year2023
TitleMyelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Journal AbbreviationNature
AuthorsDepp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, Damkou A, Zampar S, Wirths O, Thalmann M, Simons M, Saito T, Saido T, Krueger-Burg D, Kawaguchi R, Willem M, Haass C, Geschwind D, Ehrenreich H, Stassart R, Nave K
First AuthorDepp C
Last AuthorNave K

 External Resources

 nature.c...sticky  Article fulltext

 GSE178304  NCBI GEO Dataset (GSE178304)

 GSE178296  NCBI GEO Dataset (GSE178296)

 GSE208683  NCBI GEO Dataset (GSE208683)

 GSE178295  NCBI GEO Dataset (GSE178295)

 0000-0003-2868-6932  ORCID identifier (Constanze Depp)

 0000-0002-7104-7215  ORCID identifier (Ting Sun)

 0000-0002-0308-0144  ORCID identifier (Lena Spieth)

 0000-0001-7913-2716  ORCID identifier (Agnes A. Steixner-Kumar)

 0000-0002-9535-9395  ORCID identifier (Torben Ruhwedel)

 0000-0002-2902-7165  ORCID identifier (Wiebke Möbius)

 0000-0003-3507-9604  ORCID identifier (Gesine Saher)

 0000-0002-7710-5738  ORCID identifier (Hauke B. Werner)

 0000-0002-5082-0790  ORCID identifier (Alkmini Damkou)

 0000-0003-0134-0974  ORCID identifier (Silvia Zampar)

 0000-0002-4115-0334  ORCID identifier (Oliver Wirths)

 0000-0002-0610-210X  ORCID identifier (Maik Thalmann)

 0000-0001-5329-192X  ORCID identifier (Mikael Jakob Simons)

 0000-0003-1970-6903  ORCID identifier (Takaomi Saido)

 0000-0001-5597-6287  ORCID identifier (Dilja Krueger-Burg)

 0000-0002-4869-1627  ORCID identifier (Christian Haass)

 0000-0003-2896-3450  ORCID identifier (Daniel Geschwind)

 0000-0001-8371-5711  ORCID identifier (Hannelore Maria Ehrenreich)

 0000-0001-8724-9666  ORCID identifier (Klaus-Armin Nave)

 2/61  Research Data Archive (supplemental material)

 043j0f473  ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)

 03av75f26  ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

 025z3z560  ROR identifier (025z3z560, Munich Cluster for Systems Neurology)

 02kkvpp62  ROR identifier (02kkvpp62, Technical University of Munich)

 SCR_018000  SciCrunch identifier (RRID:SCR_018000, arivis Vision4D)

 SCR_017344  SciCrunch identifier (RRID:SCR_017344, Cell Ranger)

 SCR_015687  SciCrunch identifier (RRID:SCR_015687, DESeq2)

 SCR_014583  SciCrunch identifier (RRID:SCR_014583, FastQC)

 SCR_012919  SciCrunch identifier (RRID:SCR_012919, featureCounts)

 SCR_002285  SciCrunch identifier (RRID:SCR_002285, Fiji)

 SCR_002798  SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_018863  SciCrunch identifier (RRID:SCR_018863, Imspector)

 SCR_016340  SciCrunch identifier (RRID:SCR_016340, MAST)

 SCR_007322  SciCrunch identifier (RRID:SCR_007322, Seurat)

 SCR_015899  SciCrunch identifier (RRID:SCR_015899, STAR)

 SCR_005223  SciCrunch identifier (RRID:SCR_005223, STRING)

 SCR_018217  SciCrunch identifier (RRID:SCR_018217, UMAP)

 SCR_013672  SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)

 static-c...SM.pdf  Supplemental material

 github.c...nt.git  Supplemental material (code)  Supplemental material (goeseek study)

 static-c...SM.pdf  Supplemental material (reporting summary)

 static-c...M.xlsx  Supplemental material (table)

 static-c...M.xlsx  Supplemental material (table)

 static-c...M.xlsx  Supplemental material (source data)

Linked Antibodies

PIDAGTypeAntigen symbolAntibody Registry IDName
primary-0039primaryAPPAB_94882Anti-APP A4 Antibody
primary-0082primaryIba1AB_839504Anti Iba1, Rabbit (for Immunocytochemistry)
primary-0083primaryAB_2564653Purified anti-β-Amyloid, 1-16 Antibody (Previously Covance catalog# SIG-39320)
primary-0084primaryCNPAB_2665789Monoclonal Anti-CNP Antibody
primary-0085primaryBACE1Recombinant Anti-BACE1 antibody [EPR19523] (ab183612)
primary-0086primaryGFAPAB_563739Anti-Glial Fibrillary Acidic Protein Monoclonal Antibody, Unconjugated
primary-0087primaryAPPAB_258409Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit
primary-0088primaryAPPAB_2056967APP antibody
primary-0089primaryAPPAB_2798041β-Amyloid (1-42) (D3E10) Rabbit mAb
primary-0090primaryApoEAB_2798191ApoE (pan) (D7I9N) Rabbit mAb
primary-0091primaryPSN2AB_882202Recombinant Anti-Presenilin 2/AD5 antibody [EP1515Y]
primary-0096primaryBACE1AB_1903900BACE1 (D10E5) Rabbit mAb
primary-0097primaryTREM2AB_2799888TREM2 (E7P8J) Rabbit mAb (Carboxy-terminal Antigen)
secondary-0015secondaryAB_2535849Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0019secondaryAB_2535844Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0092secondaryAB_1307538Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 633
secondary-0093secondaryAB_162543Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0094secondaryAB_1965953Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, DyLight™ 633
secondary-0095secondaryAB_844397Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 488
secondary-0098secondaryAB_2556616Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, DyLight™ 800
secondary-0099secondaryAB_614942Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 680

Linked Mouselines

Research GroupPIDNameCreated