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Publication

Property	Value
Working Groups	RG Ehrenreich, RG Nave, RG Simons
Subproject	C01
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	37258678
DOI	10.1038/s41586-023-06120-6
Publication Year	2023
Title	Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Journal	Nature
ISSN	0028-0836
eISSN	1476-4687
URL	http://dx.doi.org/10.1038/s41586-023-06120-6
Journal Abbreviation	Nature
Authors	Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, Damkou A, Zampar S, Wirths O, Thalmann M, Simons M, Saito T, Saido T, Krueger-Burg D, Kawaguchi R, Willem M, Haass C, Geschwind D, Ehrenreich H, Stassart R, Nave K
First Author	Depp C
Last Author	Nave K

External Resources

nature.c...stickyhttps://www.nature.com/articles/s41586-023-06120-6.pdf?pdf=button%20sticky Article fulltext

GSE178304https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178304 NCBI GEO Dataset (GSE178304)

GSE178296https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178296 NCBI GEO Dataset (GSE178296)

GSE208683https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE208683 NCBI GEO Dataset (GSE208683)

GSE178295https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178295 NCBI GEO Dataset (GSE178295)

0000-0003-2868-6932https://orcid.org/0000-0003-2868-6932 ORCID identifier (Constanze Depp)

0000-0002-7104-7215https://orcid.org/0000-0002-7104-7215 ORCID identifier (Ting Sun)

0000-0002-0308-0144https://orcid.org/0000-0002-0308-0144 ORCID identifier (Lena Spieth)

0000-0001-7913-2716https://orcid.org/0000-0001-7913-2716 ORCID identifier (Agnes A. Steixner-Kumar)

0000-0002-9535-9395https://orcid.org/0000-0002-9535-9395 ORCID identifier (Torben Ruhwedel)

0000-0002-2902-7165https://orcid.org/0000-0002-2902-7165 ORCID identifier (Wiebke Möbius)

0000-0003-3507-9604https://orcid.org/0000-0003-3507-9604 ORCID identifier (Gesine Saher)

0000-0002-7710-5738https://orcid.org/0000-0002-7710-5738 ORCID identifier (Hauke B. Werner)

0000-0002-5082-0790https://orcid.org/0000-0002-5082-0790 ORCID identifier (Alkmini Damkou)

0000-0003-0134-0974https://orcid.org/0000-0003-0134-0974 ORCID identifier (Silvia Zampar)

0000-0002-4115-0334https://orcid.org/0000-0002-4115-0334 ORCID identifier (Oliver Wirths)

0000-0002-0610-210Xhttps://orcid.org/0000-0002-0610-210X ORCID identifier (Maik Thalmann)

0000-0001-5329-192Xhttps://orcid.org/0000-0001-5329-192X ORCID identifier (Mikael Jakob Simons)

0000-0003-1970-6903https://orcid.org/0000-0003-1970-6903 ORCID identifier (Takaomi Saido)

0000-0001-5597-6287https://orcid.org/0000-0001-5597-6287 ORCID identifier (Dilja Krueger-Burg)

0000-0002-4869-1627https://orcid.org/0000-0002-4869-1627 ORCID identifier (Christian Haass)

0000-0003-2896-3450https://orcid.org/0000-0003-2896-3450 ORCID identifier (Daniel Geschwind)

0000-0001-8371-5711https://orcid.org/0000-0001-8371-5711 ORCID identifier (Hannelore Maria Ehrenreich)

0000-0001-8724-9666https://orcid.org/0000-0001-8724-9666 ORCID identifier (Klaus-Armin Nave)

2/61https://rdp.sfb274.de/archive/2/61 Research Data Archive (supplemental material)

043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)

03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

025z3z560https://ror.org/025z3z560 ROR identifier (025z3z560, Munich Cluster for Systems Neurology)

02kkvpp62https://ror.org/02kkvpp62 ROR identifier (02kkvpp62, Technical University of Munich)

SCR_018000https://scicrunch.org/resolver/SCR_018000 SciCrunch identifier (RRID:SCR_018000, arivis Vision4D)

SCR_017344https://scicrunch.org/resolver/SCR_017344 SciCrunch identifier (RRID:SCR_017344, Cell Ranger)

SCR_015687https://scicrunch.org/resolver/SCR_015687 SciCrunch identifier (RRID:SCR_015687, DESeq2)

SCR_014583https://scicrunch.org/resolver/SCR_014583 SciCrunch identifier (RRID:SCR_014583, FastQC)

SCR_012919https://scicrunch.org/resolver/SCR_012919 SciCrunch identifier (RRID:SCR_012919, featureCounts)

SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)

SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

SCR_018863https://scicrunch.org/resolver/SCR_018863 SciCrunch identifier (RRID:SCR_018863, Imspector)

SCR_016340https://scicrunch.org/resolver/SCR_016340 SciCrunch identifier (RRID:SCR_016340, MAST)

SCR_007322https://scicrunch.org/resolver/SCR_007322 SciCrunch identifier (RRID:SCR_007322, Seurat)

SCR_015899https://scicrunch.org/resolver/SCR_015899 SciCrunch identifier (RRID:SCR_015899, STAR)

SCR_005223https://scicrunch.org/resolver/SCR_005223 SciCrunch identifier (RRID:SCR_005223, STRING)

SCR_018217https://scicrunch.org/resolver/SCR_018217 SciCrunch identifier (RRID:SCR_018217, UMAP)

SCR_013672https://scicrunch.org/resolver/SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM1_ESM.pdf Supplemental material

github.c...nt.githttps://github.com/TSun-tech/AD_MyelinMutant.git Supplemental material (code)

goeseek.gwdguser.de/studies/31https://goeseek.gwdguser.de/studies/31 Supplemental material (goeseek study)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM2_ESM.pdf Supplemental material (reporting summary)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM3_ESM.xlsx Supplemental material (table)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM4_ESM.xlsx Supplemental material (table)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06120-6/MediaObjects/41586_2023_6120_MOESM5_ESM.xlsx Supplemental material (source data)

Linked Antibodies

PID	Type	Antigen symbol	Antibody Registry ID	Name
primary-0039	primary	APP	AB_94882	Anti-APP A4 Antibody
primary-0082	primary	Iba1	AB_839504	Anti Iba1, Rabbit (for Immunocytochemistry)
primary-0083	primary		AB_2564653	Purified anti-β-Amyloid, 1-16 Antibody (Previously Covance catalog# SIG-39320)
primary-0084	primary	CNP	AB_2665789	Monoclonal Anti-CNP Antibody
primary-0085	primary	BACE1		Recombinant Anti-BACE1 antibody [EPR19523] (ab183612)
primary-0086	primary	GFAP	AB_563739	Anti-Glial Fibrillary Acidic Protein Monoclonal Antibody, Unconjugated
primary-0087	primary	APP	AB_258409	Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit
primary-0088	primary	APP	AB_2056967	APP antibody
primary-0089	primary	APP	AB_2798041	β-Amyloid (1-42) (D3E10) Rabbit mAb
primary-0090	primary	ApoE	AB_2798191	ApoE (pan) (D7I9N) Rabbit mAb
primary-0091	primary	PSN2	AB_882202	Recombinant Anti-Presenilin 2/AD5 antibody [EP1515Y]
primary-0096	primary	BACE1	AB_1903900	BACE1 (D10E5) Rabbit mAb
primary-0097	primary	TREM2	AB_2799888	TREM2 (E7P8J) Rabbit mAb (Carboxy-terminal Antigen)
secondary-0015	secondary		AB_2535849	Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0019	secondary		AB_2535844	Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0092	secondary		AB_1307538	Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 633
secondary-0093	secondary		AB_162543	Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555
secondary-0094	secondary		AB_1965953	Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, DyLight™ 633
secondary-0095	secondary		AB_844397	Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 488
secondary-0098	secondary		AB_2556616	Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, DyLight™ 800
secondary-0099	secondary		AB_614942	Goat anti-Mouse IgG (H+L) Secondary Antibody, DyLight™ 680

Linked Mouselines

Research Group	PID	Name	Created
	umg-mlc-mouseline-0001	C57BL/6J	2021-02-25

Martina Weig
Universitätsmedizin Göttingen
Institut für Neuroimmunologie und Multiple
Sklerose Forschung
Von-Siebold-Str. 3 a, 37075 Göttingen
Tel: +49-(0)-551-39-61143

External Resources

Linked Antibodies

Linked Mouselines

Coordination Munich

E-mail: adinda.wens@tum.de

Coordination Göttingen

E-mail: martina.weig@med.uni-goettingen.de

Funded by

Platform based on

Technical Support: it-support@sfb274.de Imprint