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Neurofilament Light Chain Serum Levels Mirror Age and Disability in Secondary Progressive Multiple Sclerosis |
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Innate immune memory after brain injury drives inflammatory cardiac dysfunction |
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Combining array tomography with electron tomography provides insights into leakiness of the blood-brain barrier in mouse cortex. |
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TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions |
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BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis |
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Nonvesicular lipid transfer drives myelin growth in the central nervous system |
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Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury |
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Targeting B Cells and Microglia in Multiple Sclerosis With Bruton Tyrosine Kinase Inhibitors | | Dybowski S, Torke S, Weber MS | JAMA Neurology | 2023 | | |
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Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex |
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Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease |
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Ex vivo immunocapture and functional characterization of cell-type-specific mitochondria using MitoTag mice | | de Mello NP, Fecher C, Pastor AM, Perocchi F, Misgeld T | Nature Protocols | 2023 | | |
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease |
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Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury |
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Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging |
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Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease | | Ziegler KA, Ahles A, (...), Engelhardt S | Science | 2023 | | |
Regulation of the programmed cell death protein 1/programmed cell death ligand 1axis in relapsing-remitting multiple sclerosis | | Tsaktanis T, Linnerbauer M, (...), Rothhammer V | Brain Communications | 2023 | | |
Erythropoietin re-wires cognition-associated transcriptional networks |
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Expanding the function of oligodendrocytes to brain energy metabolism | | Nave K, Asadollahi E, Sasmita A | Current Opinion in Neurobiology | 2023 | | |
Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis? |
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PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation |
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A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model |
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Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions |
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Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies |
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Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain |
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Characteristics, Prevalence, and Clinical Relevance of Juxtacortical Paramagnetic Rims in Patients With Multiple Sclerosis | | Galbusera R, Bahn E, (...), Granziera C | Neurology | 2023 | | |
An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex |
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3d Virtual Histology Reveals Pathological Alterations of Cerebellar Granule Cells in Multiple Sclerosis |
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Evaluation of Novel Enhancer Compounds in Gentamicin-Mediated Readthrough of Nonsense Mutations in Rett Syndrome |
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Reactive oxygen species produced by myeloid cells in psoriasis as a potential biofactor contributing to the development of vascular inflammation |
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The role of intrathecal free light chains kappa for the detection of autoimmune encephalitis in subacute onset neuropsychiatric syndromes |
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Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity |
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Association of retinal vessel pathology and brain atrophy in relapsing-remitting multiple sclerosis |
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Toward identifying key mechanisms of progression in multiple sclerosis |
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A fluorescence microscopy-based protocol for volumetric measurement of lysolecithin lesion-associated de- and re-myelination in mouse brain |
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The lung microbiome regulates brain autoimmunity | | Hosang L, Canals RC, (...), Odoardi F | Nature | 2022 | | |
A new form of axonal pathology in a spinal model of neuromyelitis optica |
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Myelin lipids as nervous system energy reserves |
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Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain |
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Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis |
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Size‐Selective Transfer of Lipid Nanoparticle‐Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury |
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Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance |
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Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno‐Associated Viral Vector rAAV9P1 |
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Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation |
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CNS Treg cells have alternative functions but run on conventional fuel |
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Distinct roles of the meningeal layers in CNS autoimmunity |
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P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica |
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IL-24 intrinsically regulates Th17 cell pathogenicity in mice |
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Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia |
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DNA-PAINT MINFLUX nanoscopy |
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Ketogenic diet uncovers differential metabolic plasticity of brain cells |
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For decades against the mainstream – from erythropoietin and hypoxia as novel treatment strategies to deep phenotyping in neuropsychiatric disorders | | Ehrenreich H | Psychiatry Research | 2022 | | |
Ganglioside lipidomics of central nervous system myelination using direct infusion shotgun mass spectrometry |
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CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging |
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CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities |
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Factors predisposing to humoral autoimmunity against brain-antigens in health and disease Analysis of 49 autoantibodies in over 7000 subjects |
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A deep learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders |
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Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity |
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TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury | | Zambusi A, Novoselc KT, (...), Ninkovic J | Nature Neuroscience | 2022 | | |
Cognate microglia–T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology | | Haimon Z, Frumer GR, (...), Jung S | Nature Immunology | 2022 | | |
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Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis |
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MCU controls melanoma progression through a redox‐controlled phenotype switch |
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Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain |
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Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury | | Van Steenbergen V, Burattini L, (...), Bareyre FM | Journal of Experimental Medicine | 2022 | | |
Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status |
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Hemorrhagic lesion with detection of infected endothelial cells in human bornavirus encephalitis |
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Probing cell identity hierarchies by fate titration and collision during direct reprogramming |
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Brain injury environment critically influences the connectivity of transplanted neurons |
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Cellular and Molecular Determinants of Retinal Cell Fate | | Petridou E, Godinho L | Annual Review of Vision Science | 2022 | | |
Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation |
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The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the TH17 lineage in humans |
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Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling |
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Neural labeling and manipulation by neonatal intraventricular viral injection in mice |
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Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43 |
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White matter integrity in mice requires continuous myelin synthesis at the inner tongue |
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Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation |
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Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain |
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Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19 |
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Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. |
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Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation |
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Completion of neuronal remodeling prompts myelination along developing motor axon branches | | Wang M, Kleele T, (...), Brill MS | Journal of Cell Biology | 2021 | | |
Myelin biogenesis is associated with pathological ultrastructure that is resolved by microglia during development |
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The Positive Switching Fluorescent Protein Padron2 Enables Live-Cell Reversible Saturable Optical Linear Fluorescence Transitions (RESOLFT) Nanoscopy without Sequential Illumination Steps. |
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Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies | | Heindl S, Ricci A, (...), Liesz A | Journal of Experimental Medicine | 2021 | | |
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Concurrent axon and myelin destruction differentiates X‐linked adrenoleukodystrophy from multiple sclerosis |
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Chemogenetic approaches to unravel circuit wiring and related behavior after spinal cord injury |
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Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis |
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Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus |
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TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination | | Gouna G, Klose C, (...), Simons M | Journal of Experimental Medicine | 2021 | | |
Notch-mediated re-specification of neuronal identity during central nervous system development |
| Engerer P, Petridou E, (...), Godinho L | Current Biology | 2021 | | |
Repositioning TH cell polarization from single cytokines to complex help | | Tuzlak S, Dejean AS, (...), Becher B | Nature Immunology | 2021 | | |
Addressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues |
| Begemann M, Gross O, (...), Ehrenreich H | Molecular Medicine | 2021 | | |
Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery |
| Penkert H, Bertrand A, (...), Simons M | Cell Reports | 2021 | | |
Río‐Hortega's drawings revisited with fluorescent protein defines a cytoplasm‐filled channel system of CNS myelin |
| Edgar JM, McGowan E, (...), Boullerne A | Journal of Anatomy | 2021 | | |
Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders |
| Aly L, Strauß E, (...), Knier B | Multiple Sclerosis Journal | 2021 | | |
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy |
| Kettwig M, Ternka K, (...), Gärtner J | Nature Communications | 2021 | | |
Role of IL-6 in the commitment of T cell subsets |
| Korn T, Hiltensperger M | Cytokine | 2021 | | |
The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels |
| Brüser C, Keller-Findeisen J, Jakobs S | Cell Reports | 2021 | | |
Coming to the Rescue: Regulatory T Cells for Promoting Recovery After Ischemic Stroke | | Zhang Y, Liesz A, Li P | Stroke | 2021 | | |
Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography |
| Eckermann M, Schmitzer B, (...), Salditt T | Proceedings of the National Academy of Sciences of the United States of America | 2021 | | |
A macrophage-T cell coculture model for severe tissue injury-induced T cell death |
| Zhu J, Cao J, Liesz A, Roth S | STAR Protocols | 2021 | | |
NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with neuropsychiatric relevance |
| Arinrad S, Wilke JBH, (...), Ehrenreich H | Molecular Psychiatry | 2021 | | |
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity |
| Riera-Tur I, Schäfer T, (...), Dudanova I | Life Science Alliance | 2021 | | |
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity |
| Hiltensperger M, Beltrán E, (...), Korn T | Nature Immunology | 2021 | | |
Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology |
| Schifferer M, Snaidero N, Djannatian M, Kerschensteiner M, Misgeld T | Frontiers in Neuroanatomy | 2021 | | |
Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice |
| Gil-Pulido J, Amézaga N, (...), Zernecke A | Cardiovasc Res | 2021 | | |
Identification of covalent modifications regulating immune signaling complex composition and phenotype |
| Frauenstein A, Ebner S, (...), Meissner F | Molecular Systems Biology | 2021 | | |
The Aryl Hydrocarbon Receptor–Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis |
| Cirac A, Tsaktanis T, (...), Rothhammer V | Neurology-Neuroimmunology & Neuroinflammation | 2021 | | |
The Gut-Brain Axis in Inflammatory Bowel Disease - Current and Future Perspectives |
| Günther C, Rothhammer V, Karow M, Neurath M, Winner B | International Journal of Molecular Sciences | 2021 | | |
Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury |
| Bareyre F, Fourneau J | Neural Regeneration Research | 2021 | | |
Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation |
| Eira J, Magalhães J, (...), Liz MA | Frontiers in Cell and Developmental Biology | 2021 | | |
TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics |
| Senís E, Esgleas M, (...), Abad M | Frontiers in Cell and Developmental Biology | 2021 | | |
Correction: Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2 |
| Kempf J, Knelles K, (...), Masserdotti G | Cell Reports | 2021 | | |
Neuronal replacement: Concepts, achievements, and call for caution |
| Götz M, Bocchi R | Current Opinion in Neurobiology | 2021 | | |
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells |
| Wenzel J, Lampe J, (...), Schwaninger M | Nature Neuroscience | 2021 | | |
Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study |
| Tampe D, Hakroush S, (...), Tampe B | Frontiers in Medicine | 2021 | | |
LC-MS Based Platform Simplifies Access to Metabolomics for Peroxisomal Disorders |
| Klemp HG, Kettwig M, Streit F, Gärtner J, Rosewich H, Krätzner R | Metabolites | 2021 | | |
Targeted metabolomics revealed changes in phospholipids during the development of neuroinflammation in Abcd1tm1Kds mice and X‐linked adrenoleukodystrophy patients |
| Kettwig M, Klemp H, (...), Gärtner J | Journal of Inherited Metabolic Disease | 2021 | | |
Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2 |
| Kempf J, Knelles K, (...), Masserdotti G | Cell Reports | 2021 | | |
Plasma lipidomics of monozygotic twins discordant for multiple sclerosis. |
| Penkert H, Lauber C, (...), Simons M | Annals of Clinical and Translational Neurology | 2020 | | |
Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury. |
| Pan H, Steixner-Kumar AA, (...), Ehrenreich H | Molecular Psychiatry | 2020 | | |
Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon. |
| Zambusi A, Pelin Burhan Ö, Di Giaimo R, Schmid B, Ninkovic J | Cells | 2020 | | |
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. | | Mukherjee C, Kling T, (...), Simons M | Cell Metabolism | 2020 | | |
Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. |
| LaClair KD, Zhou Q, (...), Edbauer D | Acta Neuropathologica | 2020 | | |
Formation of somatosensory detour circuits mediates functional recovery following dorsal column injury. |
| Granier C, Schwarting J, (...), Bareyre FM | Scientific Reports | 2020 | | |
Myelin replacement triggered by single-cell demyelination in mouse cortex |
| Snaidero N, Schifferer M, Mezydlo A, Zalc B, Kerschensteiner M, Misgeld T | Nature Communications | 2020 | | |
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. |
| Cantuti-Castelvetri L, Ojha R, (...), Simons M | Science | 2020 | | |
Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution |
| Kislinger G, Gnägi H, Kerschensteiner M, Simons M, Misgeld T, Schifferer M | iScience | 2020 | | |
Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. |
| Fitzner D, Bader JM, (...), Simons M | Cell Reports | 2020 | | |
Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. |
| Cunha MI, Su M, (...), Simons M | Journal of Experimental Medicine | 2020 | | |
Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination. |
| Lohrberg M, Winkler A, (...), Barrantes-Freer A | Acta Neuropathologica Communications | 2020 | | |
Remyelination in multiple sclerosis: from basic science to clinical translation. |
| Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B | Lancet Neurology | 2020 | | |
Molecular signature of slowly expanding lesions in progressive multiple sclerosis. |
| Jäckle K, Zeis T, (...), Brück W | Brain | 2020 | | |
Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. |
| Gruenenfelder FI, McLaughlin M, (...), Edgar JM | Brain | 2020 | | |
ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex. |
| Kislinger G, Gnägi H, Kerschensteiner M, Simons M, Misgeld T, Schifferer M | STAR Protocols | 2020 | | |
MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis |
| Wildemann B, Jarius S, Franz J, Ruprecht K, Reindl M, Stadelmann C | Acta Neuropathologica | 2020 | | |
Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal | | Baumann T, Dunkel A, (...), Höchst B | Nature Immunology | 2020 | | |